Kathleen Postle and Hema Vakharia are in the School of Molecular Biosciences, Washington State University, 301 Science Hall, Pullman, Washington 99164-4233, USA
Correspondence should be addressed to Kathleen Postle postle@wsu.edu
The crystal structure of TolC, one of the most mysterious proteins in the outer membrane of Gram-negative bacteria, suggests a mechanism for its role in secretion of proteins and efflux of toxic chemicals.