Role of zinc ion in translational accuracy becomes crystal clear
Karin Musier-Forsyth
& Penny J. Beuning
Karin Musier-Forsyth and Penny J. Beuning are in the Department of Chemistry, University of Minnesota, Minneapolis, Minnesota, 55455.
Correspondence should be addressed to Karin Musier-Forsyth musier@chem.umn.edu
Aminoacyl-tRNA synthetases play a central role in assuring a high degree of accuracy in protein synthesis. New high resolution structures of threonyl-tRNA synthetase bound to threonine or a threonyl-adenylate analog reveal how an active site zinc atom contributes to translational fidelity.
