Sarah A. Woodson is in the T. C. Jenkins Department
of Biophysics, Johns Hopkins University, 3400 N. Charles Street
, Baltimore, Maryland 21218-2685,
USA. swoodson@jhu.edu
Large ribozymes collapse to compact structures that are non-native
and partially disordered when folding is induced by magnesium ions. This suggests
that the early steps in the folding of these RNAs are non-specific.
