Nature Structural Biology
7, 347 - 349 (2000)
doi:10.1038/75103
Sec1 gets a grip on syntaxinPhyllis I. Hanson
Phyllis I. Hanson is in the Department of Cell Biology & Physiology, Washington University School of Medicine, 660 S. Euclid, Campus Box 8228, St. Louis, Missouri 63110, USA.
phanson@cellbio.wustl.edu
Neuronal-Sec1 and syntaxin 1a, two proteins essential for membrane fusion, have now been crystallized in a complex with each other. The structure shows how the horseshoe-shaped nSec1 surrounds and holds syntaxin in a new conformation, and suggests that conformational changes in both nSec1 and syntaxin must take place for membrane fusion to proceed.
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