Recognizing misfolded proteins in the endoplasmic reticulum
Andreas Matouschek
Andreas Matouschek is in the Department of Biochemistry,
Molecular Biology and Cell Biology, Northwestern University, Evanston
, Illinois 60208-3500, USA. matouschek@northwestern.edu
The mechanism by which cells recognize misfolded proteins in the
endoplasmic reticulum has been defined at the cell biological level. The enzyme
UDP-glucose:glycoprotein glucosyltransferase identifies and specifically glucosylates
misfolded domains within a multi-domain protein.
