Understanding membrane protein structure by design
James U. Bowie
James U. Bowie is in the Department of Chemistry and
Biochemistry and Laboratory of Structural Biology and Molecular Medicine,
MBI, University of California, Los Angeles, 611 Charles
E. Young Dr. E., Los Angeles, California
90095-1570, USA. bowie@mbi.ucla.edu
In contrast to soluble proteins, the primary interactions that specify
and stabilize membrane protein structures are still largely a matter of speculation.
Although van der Waals interactions have been gaining increasing favor as
the dominant player, new results demonstrate the strength of hydrogen bonding
in a membrane environment.
