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The recently solved crystal structures of the yeast and bovine poly(A) polymerases add to the growing list of high resolution RNA polymerase structures and provide a basis for understanding the specifics of template-independent RNA polymerization.
The crystal structure of the CooA protein yields potential insight into the general mechanism of allostery within the CAP family of transcriptional regulators.
Limitations of the three putative mechanisms of amyloid fibril assembly for explaining Sup35 prion formation have led to the introduction of a fourth model — nucleated conformational conversion — that invokes oligomeric intermediates for initiation and assembly.
