Jeffery W. Kelly is in the Skaggs Institute of Chemical Biology, Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA. jkelly@scripps.edu
Limitations of the three putative mechanisms of amyloid fibril assembly for explaining Sup35 prion formation have led to the introduction of a fourth model — nucleated conformational conversion — that invokes oligomeric intermediates for initiation and assembly.
