Phoebe A. Rice is at the Department of Biochemistry
and Molecular Biology, University of Chicago, 920 E. 58th Street
, Chicago, Illinois 60637, USA
. price@midway.uchicago.edu
The mammalian X-ray cross-complementing group 1 protein (XRCC1) is an important
player in base excision repair of damaged DNA. Two new findings help to elucidate
its role — biochemical data suggest that this multidomain protein interacts
not only with three different enzymes, but also with the nicked DNA itself,
and NMR data reveal the structure of the domain that interacts with both DNA
polymerase and DNA.
and DNA.
