S.R. Hubbard is in the Department of Pharmacology and
Skirball Institute of Biomolecular Medicine, New York University School of
Medicine, New York, NY 10016, USA
. hubbard@tallis.med.nyu.edu
Src family tyrosine kinases are key cellular signaling enzymes whose catalytic
activities are tightly controlled. Recent structural and mutational studies
have revealed additional intricacies in the autoinhibitory mechanisms by which
catalytic activity is repressed.
