J.T.J. Lecomte and C.J. Falzone are in the Chemistry Department, Pennsylvania State University, University Park, Pennsylvania, 16802, USA.
Correspondence should be addressed to Juliette T.J. Lecomte jtl1@psu.edu
A detailed NMR description of the compact unfolded state of an unstable protein reveals the existence of native and non-native structure under non-denaturing conditions. The structural characterization of this and similar species may provide clues about protein folding mechanisms.
