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Nature Structural Biology  6, 499 - 502 (1999)
doi:10.1038/9264

Two domains and one RNA: a molecular threesome

Frederick M. Hughson & Paul Schedl

Frederick M. Hughson and Paul Schedl are in the Department of Molecular Biology at Princeton University, Princeton, New Jersey 08544, USA.

Correspondence should be addressed to Frederick M. Hughson hughson@princeton.edu or Paul Schedl pschedl@molbio.princeton.edu.
Structures of the Drosophila Sex-lethal protein with and without bound RNA reveal an unexpected mode of binding in which tripartite interactions between the two RNA-binding domains and the bound RNA generate specific, high-affinity binding.

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Nature Structural & Molecular Biology
ISSN: 1545-9993
EISSN: 1545-9985
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