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If the loop fits...

Abstract

The structure of the yeast L30 ribosomal protein bound to its autoregulatory RNA site has been determined by NMR spectroscopy. The intricate architecture of the RNA internal loop and the structure of the binding region of the protein both are stabilized in the complex, highlighting the importance of mutually-induced fit in RNA–protein interactions.

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Figure 1: a, The RNA used in the NMR studies of the L30 pre-mRNA autoregulatory site complex.
Figure 2: a, NMR structure of the Saccharomyces cerevisiae L30 ribosomal protein bound to its autoregulatory RNA site1 and b, crystal structure of the Bacillus stearothermophilus L11 ribosomal protein bound to its ribosomal RNA site8.
Figure 3: a, Crystal structure of the Bacillus stearothermophilus L9 ribosomal protein34, b, crystal structure of the Thermus thermophilus S7 ribosomal protein19, and c, NMR structure of the bovine immunodeficiency virus Tat RNA-binding peptide bound to TAR RNA23.

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Frankel, A. If the loop fits.... Nat Struct Mol Biol 6, 1081–1083 (1999). https://doi.org/10.1038/70002

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