Kristin A. Marshall and Andrew D. Ellington are in the
Department of Chemistry and Biochemistry, Institute for Cellular and Molecular
Biology, University of Texas at Austin, Austin, Texas
78712, USA.
Ribozymes that are sensitive to cyclic nucleotides have been selected in vitro. Remarkably, the cGMP-dependent ribozymes are specifically activated
by a factor of 5,000 — the largest allosteric ribozyme activation by
a small molecule seen to date.
