1Xavier Ysern is in the Center for Drug Evaluation and Research,United States Food and Drug Administration, 5600 Fishers Lane, Rockville, Maryland 20857, USA.
2Hongmin Li and Roy A. Mariuzza is in the Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, 9600 Gudelsky Drive, Rockville, Maryland 20850, USA.
3e-mail: mariuzza@indigo2.carb.nist.gov
The crystal structure of a T cell receptor bound to a self peptide−major histocompatibility complex antigen reveals poor shape complementarity in the interface between the two proteins, as well as large conformational changes in the T cell receptor combining site upon ligand binding.
