Nature Structural Biology
5, 259 - 263 (1998)
doi:10.1038/nsb0498-259
The alpha and beta of turning on a molecular switchEmil F. Pai1
1Emil F. Pai is at the Departments of Biochemistry, Medical Biophysics and Medical Genetics and Microbiology, University of Toronto, 1 King's College Circle, Toronto, Ontario, M5S 1A8, Canada, and the Division of Molecular and Structural Biology, Ontario Cancer Institute, 610 University Avenue, Toronto, ON, M5G 2M9, Canada. email: pai@hera.med.utoronto.ca The crystal structures of RCC1 and the Sec7 domain of human Arno, nucleotide exchange factors for the Ras-related GTPases Ran and ARF, reveal two very different folds, the former a seven-bladed  -propeller, the latter a capped right-handed superhelix. Both are also unrelated to the folds of Mss4 and elongation factor Ts, nucleotide exchange factors for Rab and elongation factor Tu.
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