Nature Structural Biology
5, 849 - 854 (1998)
doi:10.1038/2288
Biggest virus molecular structure yet!John E. Johnson
& Vijay S. Reddy
Scripps Research Institute, Department of Molecular Biology, 10550 N. Torrey Pines Road, MB-31, La Jolla, California 92037, USA.
Correspondence should be addressed to John E. Johnson jackj@scripps.edu and or Vijay S. Reddy reddyv@scripps.eduThe blue tongue virus core (BTVC) particle is the biggest molecular structure
determined to date by X-ray crystallography. The atomic model shows that the
inner core particle of 120 VP3 subunits guides the assembly of an outer shell
with 780 VP7subunits. The structure may lead to new targets for particle based
anti-viral agents and to experiments to refine the details of the proposed
virus assembly pathway.
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