Mikael Akke1, Jun Liu2, John Cavanagh3, Harold P. Erickson4
& Arthur G. Palmer III1
1Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA.
2Pharmacology Research & Development, Genentech, Inc., South San Francisco, California 94080, USA.
3NMR Structural Biology Facility, Wadsworth Center, New York State Department of Health, Albany, NY 12201, USA.
4Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Correspondence should be addressed to A.G.P. e-mail: agp6@columbia.edu
s in the third fibronectin type III domain of human tenascin-C. Conformational fluctuations of contiguous regions of the 
-sandwich structure of the type III domain may represent collective motions, such as transient twisting or breathing of the 
