Nature Structural Biology
4, 369 - 373 (1997)
doi:10.1038/nsb0597-369
Crystal structure of the actin-binding protein actophorin from AcanthamoebaShonda A. Leonard1, Apostolos G. Gittis1, Eugene C. Petrella2, 3, Thomas D. Pollard2, 4
& Eaton E. Lattman1, 5
1Department of Biophysics and Biophysical Chemistry, Hopkins School of Medicine 725 N. Wolfe Street Baltimore, MD 21205
2Department of Cell Biology and Anatomy Johns Hopkins School of Medicine 725 N. Wolfe Street Baltimore, MD 21205
3Current address: 3-Dimensional Pharmaceutical, 665 Stockton Drive, Exton, PA 19341
4Current address: Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA 92037
5lattman@jhunix.hd.jhu.edu Actophorin is a member of the actin-depolymerizing factor/cofilin family. It severs act in filaments and sequesters actin monomers. The crystal structure of actophorin will help to elucidate actin−ADF/cofilin interactions.
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