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Nature Structural Biology  4, 331 - 333 (1997)
doi:10.1038/nsb0597-331

Pushing back the limits of electron cryomicroscopy

Wah Chiu1 & Michael F. Schmid2

  1Max-Planck Institutfur Biochemie, D-82152, Martinsriedy Germany (wah@bcm.tmc.edu)

  2Verna and Mans McLean Department of Biochemistry, Baylor College of Medicine, Houston, TX 77030

A convergence of technical advances in electron cryomicroscopy will allow visualization of biomolecular assemblies, without crystals, at resolutions below 10 Å. Recent cryomicroscopic structures of papillomavirus and hepatitis B virus capsid provide case studies.

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