Nature Structural Biology
4, 105 - 109 (1997)
doi:10.1038/nsb0297-105
Crystal structure of human cathepsin K complexed with a potent inhibitorMary E. McGrath1, 2, Jeffrey L. Klaus1, Michael G. Barnes1
& Dieter Brömme1
1Arris Pharmaceutical, 385 Oyster Point Blvd., Suite 3, South San Francisco, California 94080, USA
2mcgrath@arris.com The high resolution structure of the new therapeutic target, cathepsin K, complexed with the potent mechanism-based inhibitor, APC3328, reveals the substrate-binding sites of this cysteine proteinase and validates the binding mode for this inhibitor class.
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