Journal home
Advance online publication
Current issue
Archive
Press releases
Supplements
Focus
Guide to authors
Online submissionOnline submission
Permissions
For referees
Free online issue
Contact the journal
Subscribe
Advertising
work@npg
naturereprints
About this site
For librarians
 
NPG Resources
Nature
Nature Cell Biology
Nature Reviews Molecular Cell Biology
The EMBO Journal
Nature Reports Avian Flu
NPG Subject areas
Biotechnology
Cancer
Chemistry
Clinical Medicine
Dentistry
Development
Drug Discovery
Earth Sciences
Evolution & Ecology
Genetics
Immunology
Materials Science
Medical Research
Microbiology
Molecular Cell Biology
Neuroscience
Pharmacology
Physics
Browse all publications
Correspondence
Nature Structural Biology  4, 990 - 994 (1997)
doi:10.1038/nsb1297-990

Mg2+−Mn2+ clusters in enzyme-catalyzed phosphoryl-transfer reactions

Leslie W. Tari1, Allan Matte1, Hughes Goldie2 & Louis T.J. Delbaere1, 3

  1Department of Biochemistry, University of Saskatchewan, Saskatoon, 107 Wiggins Road Saskatchewan, Canada S7N 5E5.

  2Department of Microbiology, University of Saskatchewan, Saskatoon, 107 Wiggins Road Saskatchewan, Canada S7N 5E5.

  3delbaere@sask.usask.ca

Here we show how Mg2+ and Mn2+ function in Escherichia coli phosphoenolpyruvate carboxykinase (PCK) and we propose a general model for the role of binuclear metal clusters in enzyme-catalyzed phosphoryl-transfer reactions.

REFERENCES
  1. Utter, M.F. & Kolenbrander, H.M. In The Enzymes (ed. Boyer, P. D.) 117−168 (Academic Press, NY; 1972). | ChemPort |
  2. Matte, A., Tari, L.W., Goldie, H. & Delbaere, L.T.J. J. Biol. Chem. 272, 8105−8108 (1997). | Article | PubMed | ISI | ChemPort |
  3. Dismukes, G.C. Chem. Rev., 96, 2909−2926 (1996). | Article | PubMed | ISI | ChemPort |
  4. Goldie, A.H. & Sanwal, B.D. J. Biol. Chem. 255, 1399−1405 (1980). | PubMed | ISI | ChemPort |
  5. Lee, M.H., Hebda, C.A. & Nowak, T. J. Biol. Chem. 256, 12793−12801 (1981). | PubMed | ChemPort |
  6. Rohrer, S.P., Saz, H.J. & Nowak, T. Biol. Chem. 261, 13049−13055 (1986). | ChemPort |
  7. Maggini, S., Stoecklin-Tschan, F.B., Mörikofer-Zwez, S. & Walter, P. Biochem. J. 292, 365−370 (1993). | PubMed | ISI | ChemPort |
  8. Hebda, C.A. & Nowak, T. J. Biol. Chem. 257, 5515−5522 (1982). | PubMed | ISI | ChemPort |
  9. Ramakrishnan, C. & Ramachadran, G.N. Biophys. J. 5, 909−933 (1965). | PubMed | ISI | ChemPort |
  10. Matte, A., Goldie, H., Sweet, R.M. & Delbaere, L.T.J. J. Mol. Biol. 256, 126−143 (1996). | Article | PubMed | ISI | ChemPort |
  11. Tari, L.W., Matte, A., Pugazenthi, U., Goldie, H. & Delbaere, L.T.J. Nature Struct. Biol. 3, 355−363 (1996). | PubMed | ISI | ChemPort |
  12. Williams, R.J.P. In Magnesium and the Cell (ed. Birch, N. J.) 15−30 (Academic Press, London; 1993). | ChemPort |
  13. Matte, A. Ph. D. thesis, University of Saskatchewan, Saskatoon, Canada (1996).
  14. Tarn, S. -C. & Williams, R. J. P. Struct. Bond 63, 103−151 (1985).
  15. Fraústo da Silva, J. J. R. & Williams, R. J. P.. In The Biological Chemistry of the Elements: The Inorganic Chemistry of Life, 30−40 (Clarendon Press, Oxford; 1991).
  16. Berchtold, H. et al. Nature 365, 126−132 (1993) | Article | PubMed | ISI | ChemPort |
  17. Wigley, D.B. et al. Nature 351, 624−629 (1991). | Article | PubMed | ISI | ChemPort |
  18. Pai, E.F. et al. Nature 341, 209−214 (1989). | Article | PubMed | ISI | ChemPort |
  19. Colombo, G. & Lardy, H.A. Biochemistry 20, 2758−2767 (1981). | PubMed | ISI | ChemPort |
  20. Lee, M.H. & Nowak, T. Biochemistry 23, 6506−6513 (1984). | PubMed | ISI | ChemPort |
  21. Duffy, T.H. & Nowak, T. Biochemistry 24, 1152−1160 (1985). | PubMed | ISI | ChemPort |
  22. Hlavaty, J.J. & Nowak, T. Biochemistry 36, 3389−3403 (1997). | Article | PubMed | ISI | ChemPort |
  23. Sigel, H. et al. J. Am. Chem. Soc. 106, 7935−7946 (1984). | ISI | ChemPort |
  24. Sigel, H. Coord. Chem. Rev. 100, 453−539 (1990). | Article | ISI | ChemPort |
  25. Baek, Y.H. & Nowak, T. Arch. Biochem. Biophys. 217, 491−197 (1982). | PubMed | ISI | ChemPort |
  26. Frick, D.N. et al. J. Biol, Chem. 269, 1794−1803 (1994). | ISI | ChemPort |
  27. Hunt, J.B. et al. Arch. Biochem. Biophys. 166, 102−124 (1975). | PubMed | ISI | ChemPort |
  28. Balakrishnan, M.S. & Villafranca, J.J. Biochemistry 17, 3531−3538 (1978). | PubMed | ISI | ChemPort |
  29. Liaw, S-H. & Eisenberg, D. Biochemistry 33, 675−681 (1994). | PubMed | ISI | ChemPort |
  30. Lodato, D.T. & Reed, G.H. Biochemistry 26, 2243−2250 (1987). | PubMed | ISI | ChemPort |
  31. Buchbinder, J.L. & Reed, G.H. Biochemistry 29, 1799−1806 (1990). | PubMed | ISI | ChemPort |
  32. Fraústo da Silva, J. J. R. & Williams, R. J. P.. In The biological chemistry of the elements: the inorganic chem-istry of life, 247 (Clarendon Press, Oxford; 1991).
  33. Collaborative Computational Project sharp 4, Acta Crys-tallogr. D50, 760−763 (1994).
  34. French, S. & Wilson, K. Acta Crystallogr. A34 517−525 (1978). | ChemPort |
  35. Brünger, A.T., Kuriyan, J. & Karplus, M. Science 235, 458−460 (1987). | ISI |
  36. Roussel, A. & Cambillau, C. TURBO FRODO. In Silicon Graphics Geometry Partner Directory, 77−88 (Silicon Graphics, Mountain View, California; 1989).
  37. Evans, S.V. J. Mol. Graphics 11, 134−138 (1993). | Article | ISI | ChemPort |
 Top
 Top
References
Previous | Next
Table of contents
Download PDFDownload PDF
Send to a friendSend to a friend
Save this linkSave this link

Open Innovation Challenges

References
Export citation
Export references
natureproducts

Search buyers guide:

 
ADVERTISEMENT
 
Nature Structural & Molecular Biology
ISSN: 1545-9993
EISSN: 1545-9985
Journal home | Advance online publication | Current issue | Archive | Press releases | Supplements | For authors | Online submission | Permissions | For referees | Free online issue | About the journal | Contact the journal | Subscribe | Advertising | work@npg | naturereprints | About this site | For librarians
Nature Publishing Group, publisher of Nature, and other science journals and reference works©1997 Nature Publishing Group | Privacy policy