Nature Structural Biology
4, 990 - 994 (1997)
doi:10.1038/nsb1297-990
Mg2+−Mn2+ clusters in enzyme-catalyzed phosphoryl-transfer reactionsLeslie W. Tari1, Allan Matte1, Hughes Goldie2
& Louis T.J. Delbaere1, 3
1Department of Biochemistry, University of Saskatchewan, Saskatoon, 107 Wiggins Road Saskatchewan, Canada S7N 5E5.
2Department of Microbiology, University of Saskatchewan, Saskatoon, 107 Wiggins Road Saskatchewan, Canada S7N 5E5.
3delbaere@sask.usask.ca Here we show how Mg2+ and Mn2+ function in Escherichia coli phosphoenolpyruvate carboxykinase (PCK) and we propose a general model for the role of binuclear metal clusters in enzyme-catalyzed phosphoryl-transfer reactions. REFERENCES
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