Nature Structural Biology
3, 113 - 115 (1996)
doi:10.1038/nsb0296-113
Nuclear receptors spring into actionMalcolm G. Parker1
& Roger White1
1Molecular Endocrinology Laboratory, Imperial Cancer Research Fund, PO Box 123,44 Lincoln's Inn Fields, London WC2A 3PX, UK The ligand-binding domain of nuclear receptors appears to contain a common fold that generates a conserved ligand-binding pocket. Their transcriptional activity is induced by ligand through realignment of a Gterminal helix to form a novel interacting surface.
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