Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

A glimpse into chromatin remodeling

Nature Structural & Molecular Biology volume 24, pages 498–500 (2017)Cite this article

Subjects

Chromatin remodelers are ATP-driven enzymes that can slide nucleosomes along DNA. Chen and colleagues present a tantalizing ∼4-Å view of the SWI/SNF ATPase motor bound to the nucleosome, which offers novel structural clues into the remodeling process.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Remodeler ATPases bind to the internal SHL2 site on the nucleosome.
Figure 2: Nucleosomal DNA contacts made by the SWI/SNF ATPase motor.

Accession codes

Accessions

Protein Data Bank

References

  1. Singleton, M.R., Dillingham, M.S. & Wigley, D.B. Annu. Rev. Biochem. 76, 23–50 (2007).

    Article  CAS  Google Scholar 

  2. Velankar, S.S., Soultanas, P., Dillingham, M.S., Subramanya, H.S. & Wigley, D.B. Cell 97, 75–84 (1999).

    Article  CAS  Google Scholar 

  3. Gu, M. & Rice, C.M. Proc. Natl. Acad. Sci. USA 107, 521–528 (2010).

    Article  CAS  Google Scholar 

  4. Saha, A., Wittmeyer, J. & Cairns, B.R. Nat. Struct. Mol. Biol. 12, 747–755 (2005).

    Article  CAS  Google Scholar 

  5. Zofall, M., Persinger, J., Kassabov, S.R. & Bartholomew, B. Nat. Struct. Mol. Biol. 13, 339–346 (2006).

    Article  CAS  Google Scholar 

  6. Deindl, S. et al. Cell 152, 442–452 (2013).

    Article  CAS  Google Scholar 

  7. Harada, B.T. et al. eLife 5, e10051 (2016).

    Article  Google Scholar 

  8. Liu, X. et al. Nature 544, 440–445 (2017).

    Article  CAS  Google Scholar 

  9. Schwanbeck, R., Xiao, H. & Wu, C. J. Biol. Chem. 279, 39933–39941 (2004).

    Article  CAS  Google Scholar 

  10. McKnight, J.N., Jenkins, K.R., Nodelman, I.M., Escobar, T. & Bowman, G.D. Mol. Cell. Biol. 31, 4746–4759 (2011).

    Article  CAS  Google Scholar 

  11. Dechassa, M.L. et al. Nucleic Acids Res. 40, 4412–4421 (2012).

    Article  CAS  Google Scholar 

  12. Nodelman, I.M. et al. Mol. Cell 65, 447–459.e6 (2017).

    Article  CAS  Google Scholar 

  13. Makde, R.D., England, J.R., Yennawar, H.P. & Tan, S. Nature 467, 562–566 (2010).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors acknowledge support from the Wellcome Trust and Cancer Research UK (D.B.W.) and the US National Institutes of Health (R01GM-084192 to G.D.B.).

Author information

Authors and Affiliations

  1. Department of Medicine, Section of Structural Biology, Imperial College London, London, UK

    Dale B Wigley

  2. T.C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, Maryland, USA

    Gregory D Bowman

Authors
  1. Dale B Wigley
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gregory D Bowman
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Dale B Wigley or Gregory D Bowman.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wigley, D., Bowman, G. A glimpse into chromatin remodeling. Nat Struct Mol Biol 24, 498–500 (2017). https://doi.org/10.1038/nsmb.3415

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsmb.3415

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing