One of the striking features of cells seen through a microscope is the heterogeneous organization of the nuclei. A combination of molecular methods and computational modeling has now been used to reconstruct accurate 3D structures of the genome inside single nuclei.
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de Wit, E. Capturing heterogeneity: single-cell structures of the 3D genome. Nat Struct Mol Biol 24, 437–438 (2017). https://doi.org/10.1038/nsmb.3404
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DOI: https://doi.org/10.1038/nsmb.3404
