Hydrogen/deuterium exchange mass spectrometry reveals that the antiapoptotic protein MCL-1 is inhibited by a covalent modification far from its functional site. This finding opens new avenues for cancer therapy, but it also highlights that much remains to be learned about the fundamental basis of allosteric regulation.
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Konermann, L. Heavy lessons in protein allostery. Nat Struct Mol Biol 23, 511–512 (2016). https://doi.org/10.1038/nsmb.3234
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DOI: https://doi.org/10.1038/nsmb.3234
