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Volume 23 Issue 1, January 2016

A nanodisc-based approach reveals that exocytotic fusion pores are composed of both membrane lipids and SNARE proteins. Cover image by © Zffoto / iStock / Thinkstock.(pp 67–73, News and Views p 5)

Correspondence

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News & Views

  • Rea1 is an ATPase related to dynein motor proteins that has been implicated in the biogenesis of the 60S ribosomal subunit. A new cryo-EM study vividly demonstrates the power of structural methods, deciphering the role of Rea1 in monitoring key pre-60S maturation steps before the acquisition of export competence in budding yeast.

    • Vadim Shchepachev
    • David Tollervey
    News & Views
  • Release of neurotransmitters occurs by opening of a fusion pore in a manner thought to be mediated by SNARE proteins, but whether the fusion pore is a lipidic or a proteinaceous structure is controversial. A new study using very small nanodiscs shows that it is both.

    • Satyan Sharma
    • Manfred Lindau
    News & Views
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Review Article

  • A comprehensive review of the discovery and molecular dissection of the eukaryotic ribosome-associated quality-control pathway for degradation of nascent proteins arising from interrupted translation.

    • Onn Brandman
    • Ramanujan S Hegde
    Review Article
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Article

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Corrigendum

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