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Grab the wiggly tail: new insights into the dynamics of circadian clocks

Nature Structural & Molecular Biology volume 22, pages 435–436 (2015)Cite this article

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How do molecular interactions determine the period length of a circadian oscillator? In mammals, a disordered region of the BMAL1 transcription factor that is able to interact with activators or repressors seems to perform this function.

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Figure 1: Model of the mammalian circadian oscillator.
Figure 2: Analysis of the differences between BMAL1 and BMAL2.

Marina Corral Spence/Nature Publishing Group

Figure 3: Properties of disordered proteins may explain differences in the function of BMAL1 and BMAL2.

Marina Corral Spence/Nature Publishing Group

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Authors and Affiliations

  1. Ka Yi Hui is at the Department of Molecular Biology, University of Geneva, Geneva, Switzerland.,

    Ka Yi Hui

  2. Jürgen A. Ripperger is at the Department of Biology, Unit of Biochemistry, University of Fribourg, Fribourg, Switzerland.,

    Jürgen A Ripperger

Authors
  1. Ka Yi Hui
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  2. Jürgen A Ripperger
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Correspondence to Jürgen A Ripperger.

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The authors declare no competing financial interests.

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Hui, K., Ripperger, J. Grab the wiggly tail: new insights into the dynamics of circadian clocks. Nat Struct Mol Biol 22, 435–436 (2015). https://doi.org/10.1038/nsmb.3039

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