Mammalian cells have both cytoplasmic and mitochondrial ribosomes, which have long been considered to operate completely independently. However, a new report shows that after heat shock, MRPL18, a human mitochondrial ribosomal protein, binds to cytoplasmic ribosomes to influence translation of heat-shock mRNAs.
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References
Jäkel, S. & Gorlich, D. EMBO J. 17, 4491–4502 (1998).
Fukasawa, Y. et al. Mol. Cell. Proteomics 14, 1113–1126 (2015).
Hällberg, B.M. & Larsson, N.G. Cell Metab. 20, 226–240 (2014).
Richter, K., Haslbeck, M. & Buchner, J. Mol. Cell 40, 253–266 (2010).
Zhang, X. et al. Nat. Struct. Mol. Biol. 22, 404–410 (2015).10.1038/nsmb.3010
Sonenberg, N. & Hinnebusch, A.G. Cell 136, 731–745 (2009).
Hinnebusch, A.G. Microbiol. Rev. 52, 248–273 (1988).
Lu, P.D., Harding, H.P. & Ron, D. J. Cell Biol. 167, 27–33 (2004).
Wek, R.C., Jiang, H.Y. & Anthony, T.G. Biochem. Soc. Trans. 34, 7–11 (2006).
Sun, J., Conn, C.S., Han, Y., Yeung, V. & Qian, S.B. J. Biol. Chem. 286, 6791–6800 (2011).
Xue, S. & Barna, M. Nat. Rev. Mol. Cell Biol. 13, 355–369 (2012).
Rubtsova, M.P. et al. J. Biol. Chem. 278, 22350–22356 (2003).
Ban, N. et al. Curr. Opin. Struct. Biol. 24, 165–169 (2014).
Brown, A. et al. Science 346, 718–722 (2014).
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Warner, J. A little less leads to lots more. Nat Struct Mol Biol 22, 350–351 (2015). https://doi.org/10.1038/nsmb.3023
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DOI: https://doi.org/10.1038/nsmb.3023
