Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Micro-terminator: 'Hasta la vista, lncRNA!'

Nature Structural & Molecular Biology volume 22, pages 279–281 (2015)Cite this article

Subjects

Transcriptional termination is an important yet incompletely understood aspect of gene expression. Proudfoot, Jopling and colleagues now identify a new Microprocessor-mediated mechanism of transcriptional termination, which acts specifically on long noncoding transcripts that serve as microRNA precursors.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: At least five different signals and mechanisms mediate transcriptional termination of RNA polymerase II.
Figure 2: Open questions for future research.

References

  1. Kuehner, J.N., Pearson, E.L. & Moore, C. Nat. Rev. Mol. Cell Biol. 12, 283–294 (2011).

    Article  CAS  Google Scholar 

  2. West, S., Gromak, N. & Proudfoot, N.J. Nature 432, 522–525 (2004).

    Article  CAS  Google Scholar 

  3. Elkon, R., Ugalde, A.P. & Agami, R. Nat. Rev. Genet. 14, 496–506 (2013).

    Article  CAS  Google Scholar 

  4. Mayr, C. & Bartel, D.P. Cell 138, 673–684 (2009).

    Article  CAS  Google Scholar 

  5. Ulitsky, I. et al. Genome Res. 22, 2054–2066 (2012).

    Article  CAS  Google Scholar 

  6. Jenal, M. et al. Cell 149, 538–553 (2012).

    Article  CAS  Google Scholar 

  7. Dominski, Z. & Marzluff, W.F. Gene 396, 373–390 (2007).

    Article  CAS  Google Scholar 

  8. O'Reilly, D. et al. Nucleic Acids Res. 42, 264–275 (2014).

    Article  CAS  Google Scholar 

  9. Gutschner, T., Hammerle, M. & Diederichs, S. J. Mol. Med. (Berl) 91, 791–801 (2013).

    Article  CAS  Google Scholar 

  10. Gutschner, T. et al. Cancer Res. 73, 1180–1189 (2013).

    Article  CAS  Google Scholar 

  11. Wilusz, J.E., Freier, S.M. & Spector, D.L. Cell 135, 919–932 (2008).

    Article  CAS  Google Scholar 

  12. Sunwoo, H. et al. Genome Res. 19, 347–359 (2009).

    Article  CAS  Google Scholar 

  13. Dhir, A., Dhir, S., Proudfoot, N.J. & Jopling, C.L. Nat. Struct. Mol. Biol. 22, 319–327 (2015).

    Article  CAS  Google Scholar 

  14. Winter, J., Jung, S., Keller, S., Gregory, R.I. & Diederichs, S. Nat. Cell Biol. 11, 228–234 (2009).

    Article  CAS  Google Scholar 

  15. Lee, Y. et al. Nature 425, 415–419 (2003).

    Article  CAS  Google Scholar 

  16. Morlando, M. et al. Nat. Struct. Mol. Biol. 15, 902–909 (2008).

    Article  CAS  Google Scholar 

  17. Ballarino, M. et al. Mol. Cell. Biol. 29, 5632–5638 (2009).

    Article  CAS  Google Scholar 

  18. Wagschal, A. et al. Cell 150, 1147–1157 (2012).

    Article  CAS  Google Scholar 

  19. Baskerville, S. & Bartel, D.P. RNA 11, 241–247 (2005).

    Article  CAS  Google Scholar 

  20. Shkumatava, A., Stark, A., Sive, H. & Bartel, D.P. Genes Dev. 23, 466–481 (2009).

    Article  CAS  Google Scholar 

  21. Dey, B.K., Pfeifer, K. & Dutta, A. Genes Dev. 28, 491–501 (2014).

    Article  Google Scholar 

  22. Klein, U. et al. Cancer Cell 17, 28–40 (2010).

    Article  CAS  Google Scholar 

  23. Garding, A. et al. PLoS Genet. 9, e1003373 (2013).

    Article  CAS  Google Scholar 

  24. Chaulk, S.G. et al. RNA Biol. 8, 1105–1114 (2011).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Sven Diederichs is at the Division 'RNA Biology & Cancer', German Cancer Research Center (DKFZ), Heidelberg, Germany, and the Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.,

    Sven Diederichs

Authors
  1. Sven Diederichs
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sven Diederichs.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Diederichs, S. Micro-terminator: 'Hasta la vista, lncRNA!'. Nat Struct Mol Biol 22, 279–281 (2015). https://doi.org/10.1038/nsmb.3001

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsmb.3001

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing