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Muscling in on the ryanodine receptor

Nature Structural & Molecular Biology volume 22, pages 106–107 (2015)Cite this article

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The ryanodine receptor (RyR), an ion channel regulating intracellular calcium release in excitable cells, has been challenging for structural analysis because of its colossal proportions compared to most other ion channels. Three independent groups have now used recent technological advancements in single-particle cryo-EM to make giant strides in solving the structure of this elusive protein complex.

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Figure 1: Cartoon representation of RyR1 structure.

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Authors and Affiliations

  1. Ivana Y. Kuo and Barbara E. Ehrlich are at the Department of Pharmacology and the Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, USA.,

    Ivana Y Kuo & Barbara E Ehrlich

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  1. Ivana Y Kuo
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  2. Barbara E Ehrlich
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Correspondence to Barbara E Ehrlich.

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The authors declare no competing financial interests.

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Kuo, I., Ehrlich, B. Muscling in on the ryanodine receptor. Nat Struct Mol Biol 22, 106–107 (2015). https://doi.org/10.1038/nsmb.2960

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