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Putting a finger in the ring

Nature Structural & Molecular Biology volume 21, pages 1025–1027 (2014)Cite this article

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Two complementary papers demonstrate that the homologous type II transmembrane proteins LAP1 and LULL1 adopt nucleotide-free AAA+ ATPase folds and donate arginine fingers to complete the active sites of Torsin AAA+ ATPases. Activated Torsin complexes appear to function in nuclear and endoplasmic reticulum membrane-remodeling processes, including a nuclear vesiculation pathway that carries large cellular and viral cargoes from the nucleus into the cytoplasm.

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Figure 1: Arginine-finger interactions in small GTPases, AAA+ ATPases and the TorsinA–LAP1 complex.
Figure 2: Locations and interactions of Torsin complexes.

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References

  1. Wendler, P., Ciniawsky, S., Kock, M. & Kube, S. Biochim. Biophys. Acta 1823, 2–14 (2012).

    Article  CAS  Google Scholar 

  2. White, S.R. & Lauring, B. Traffic 8, 1657–1667 (2007).

    Article  CAS  Google Scholar 

  3. Hanson, P.I. & Whiteheart, S.W. Nat. Rev. Mol. Cell Biol. 6, 519–529 (2005).

    Article  CAS  Google Scholar 

  4. Sosa, B.A. et al. eLife 3, e03239 (2014).

    Article  Google Scholar 

  5. Brown, R.S., Zhao, C., Chase, A.R., Wang, J. & Schlieker, C. Proc. Natl. Acad. Sci. USA 111, E4822–E4831 (2014)

    Article  CAS  Google Scholar 

  6. Tanabe, L.M., Kim, C.E., Alagem, N. & Dauer, W.T. Nat. Rev. Neurol. 5, 598–609 (2009).

    Article  CAS  Google Scholar 

  7. Granata, A. & Warner, T.T. Eur. J. Neurol. 17 (suppl. 1), 81–87 (2010).

    Article  Google Scholar 

  8. Jokhi, V. et al. Cell Rep. 3, 988–995 (2013).

    Article  CAS  Google Scholar 

  9. Speese, S.D. et al. Cell 149, 832–846 (2012).

    Article  CAS  Google Scholar 

  10. Lee, C.P. et al. PLoS Pathog. 8, e1002904 (2012).

    Article  CAS  Google Scholar 

  11. Mettenleiter, T.C., Muller, F., Granzow, H. & Klupp, B.G. Cell. Microbiol. 15, 170–178 (2013).

    Article  CAS  Google Scholar 

  12. Zhu, L., Millen, L., Mendoza, J.L. & Thomas, P.J. J. Biol. Chem. 285, 37271–37280 (2010).

    Article  CAS  Google Scholar 

  13. Ozelius, L.J. et al. Nat. Genet. 17, 40–48 (1997).

    Article  CAS  Google Scholar 

  14. Zhao, C., Brown, R.S., Chase, A.R., Eisele, M.R. & Schlieker, C. Proc. Natl. Acad. Sci. USA 110, E1545–E1554 (2013).

    Article  CAS  Google Scholar 

  15. Vander Heyden, A.B., Naismith, T.V., Snapp, E.L. & Hanson, P.I. EMBO J. 30, 3217–3231 (2011).

    Article  CAS  Google Scholar 

  16. Shin, J.Y. et al. Dev. Cell 26, 591–603 (2013).

    Article  CAS  Google Scholar 

  17. Vander Heyden, A.B., Naismith, T.V., Snapp, E.L., Hodzic, D. & Hanson, P.I. Mol. Biol. Cell 20, 2661–2672 (2009).

    Article  CAS  Google Scholar 

  18. Rose, A.E., Zhao, C., Turner, E.M., Steyer, A.M. & Schlieker, C. J. Biol. Chem. 289, 552–564 (2014).

    Article  CAS  Google Scholar 

  19. Goodchild, R.E., Kim, C.E. & Dauer, W.T. Neuron 48, 923–932 (2005).

    Article  CAS  Google Scholar 

  20. Webster, B.M., Colombi, P., Jager, J. & Lusk, C.P. Cell 159, 388–401 (2014).

    Article  CAS  Google Scholar 

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  1. John McCullough and Wesley I. Sundquist are at the Department of Biochemistry, University of Utah, Salt Lake City, Utah, USA.,

    John McCullough & Wesley I Sundquist

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  1. John McCullough
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  2. Wesley I Sundquist
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Correspondence to Wesley I Sundquist.

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McCullough, J., Sundquist, W. Putting a finger in the ring. Nat Struct Mol Biol 21, 1025–1027 (2014). https://doi.org/10.1038/nsmb.2928

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