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Volume 21 Issue 10, October 2014

A global survey of SUMOylation in human cells by Vertegaal and colleagues uncovers highly interconnected functional clusters of SUMOylated proteins and extensive crosstalk between SUMO and other post-translational modifications. Cover art by Ivo A. Hendriks. pp 927–936

Commentary

  • We report the outcomes of the discussion initiated at the workshop entitled A 3D Cellular Context for the Macromolecular World and propose how data from emerging three-dimensional (3D) cellular imaging techniques—such as electron tomography, 3D scanning electron microscopy and soft X-ray tomography—should be archived, curated, validated and disseminated, to enable their interpretation and reuse by the biomedical community.

    • Ardan Patwardhan
    • Alun Ashton
    • Gerard J Kleywegt
    Commentary Open Access

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News & Views

  • Yeast cells display synchronized oscillation between phases of high and low oxygen consumption accompanied by a program of cyclical gene expression. A study monitoring mRNA levels, histone modifications and chromatin occupancy of histone modifiers during the yeast metabolic cycle (YMC) at high temporal resolution reveals both 'just-in-time' supply of YMC gene products and new patterns of chromatin reconfiguration associated with transcriptional regulation.

    • R Magnus N Friis
    • Michael C Schultz
    News & Views
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Article

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Resource

  • High-resolution MS identifies >4,300 SUMOylation sites in >1,600 proteins in human cells under standard growth conditions and after proteasome inhibition or heat shock. The data reveal cross-talk between SUMO and other post-translational modifications.

    • Ivo A Hendriks
    • Rochelle C J D'Souza
    • Alfred C O Vertegaal
    Resource
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