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Conformational dynamics of STIM1 activation

Nature Structural & Molecular Biology volume 20, pages 918–919 (2013)Cite this article

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An Erratum to this article was published on 04 October 2013

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The binding of stromal interaction molecule 1 (STIM1) to ORAI calcium channels is critical for store-operated calcium entry (SOCE), a calcium influx pathway conserved among nearly all vertebrate cells. Although many major steps of this pathway are well understood, crucial details regarding the mechanism of STIM1 activation remain unclear. A study in this issue provides important new insights into the conformational changes that occur during STIM1 activation.

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Figure 1: Model of the structural dynamics underlying STIM1 activation and ORAI channel gating.

Change history

  • 23 August 2013

    In the version of this article initially published, "Lys251" was incorrectly substituted for "Leu251" in Figure 1 and in the text. The error has been corrected in the HTML and PDF versions of the article.

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Author information

Authors and Affiliations

  1. Stefan Feske is at the Department of Pathology, New York University School of Medicine, New York, New York, USA.,

    Stefan Feske

  2. Murali Prakriya is at the Department of Molecular Pharmacology and Biological Chemistry, Northwestern University School of Medicine, Chicago, Illinois, USA.,

    Murali Prakriya

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  1. Stefan Feske
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  2. Murali Prakriya
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Correspondence to Stefan Feske.

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Competing interests

Stefan Feske is a scientific cofounder and consultant of Calcimedica. Murali Prakriya declares no competing financial interests.

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Feske, S., Prakriya, M. Conformational dynamics of STIM1 activation. Nat Struct Mol Biol 20, 918–919 (2013). https://doi.org/10.1038/nsmb.2647

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