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Mutation of a buried residue causes loss of activity but no conformational change in the heat-labile enterotoxin of Escherichia coli

Nature Structural Biology volume 2, pages 269–272 (1995)Cite this article

The structure of an inactive mutant, heat-labile enterotoxin raises the possibility of a direct functional role for an internal, water-filled cavity.

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Authors and Affiliations

  1. Department of Biological Structure SM-20, University of Washington, Seattle, Washington, 98195, USA

    Ethan A. Merritt & Wim G.J. Hol

  2. Immunobiological Research Institute Siena, Via Florentina 1, 53100, Siena, Italy

    Mariagrazia Pizza, Mario Domenighini, Rino Rappuoli & Wim G.J. Hol

  3. Howard Hughes Medical Institute SL-15, University of Washington, Seattle, Washington, 98195, USA

    Steve Sarfaty

Authors
  1. Ethan A. Merritt
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  2. Steve Sarfaty
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  3. Mariagrazia Pizza
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  4. Mario Domenighini
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  6. Wim G.J. Hol
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Merritt, E., Sarfaty, S., Pizza, M. et al. Mutation of a buried residue causes loss of activity but no conformational change in the heat-labile enterotoxin of Escherichia coli. Nat Struct Mol Biol 2, 269–272 (1995). https://doi.org/10.1038/nsb0495-269

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