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Nature Structural Biology  2, 817 - 820 (1995)
doi:10.1038/nsb1095-817

Watching protein folding unfold

Heinrich Roder1

1Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, Pennsylvania 19111, USA; and Department of Biochemistry & Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6059, USA

Direct NMR observation of a transient folding intermediate provides new evidence for the importance of molten globules as general intermediates in protein folding.

REFERENCES
  1. Kim, P.S. & Baldwin, R.L. A. Rev. Biochem. 59, 631−660 (1990). | Article | ISI | ChemPort |
  2. Matthews, C.R. A. Rev. Biochem. 62, 653−683 (1993). | Article | ISI | ChemPort |
  3. Evans, P.A. & Radford, S.E. Curr. Opin. Struct. Biol. 4, 100−106 (1994). | ISI | ChemPort |
  4. Roder, H. & Elöve, G.A. In Mechanisms of Protein Folding: Frontiers in Molecular Biology. (Ed. Pain, R.H.), 26−55 (Oxford University Press, New York; 1994). | ChemPort |
  5. Kuwajima, K. Proteins 6, 87 (1989). | PubMed | ISI | ChemPort |
  6. Ptitsyn, O.B. In Protein Folding. (Ed. Creighton, T.E.), 243−300 (W. H. Freeman & Co., New York; 1992). | ChemPort |
  7. Ptitsyn, O.B., Pain, R.H., Semisotnov, G.V., Zerovnik, E. & Razgulyaev, O.I. FEBS Lett. 262, 20 (1990). | Article | PubMed | ISI | ChemPort |
  8. Balbach, J., Forge, V., van Nuland, N.A.J., Winder, S.L., Hore, P.J. & Dobson, C.M. Nature Struct. Biology 2, 866−870 (1995).
  9. Matthews, C.R. Meth. Enzymol. 154, 498−511 (1987). | Article | PubMed | ISI | ChemPort |
  10. Matouschek, A., Kellis, J.T., Jr., Serrano, L., Bycroft, M. & Fersht, A.R. Nature 346, 440−445 (1990). | Article | PubMed | ISI | ChemPort |
  11. Fersht, A.R. FEBS Lett. 325, 5−16 (1993). | Article | PubMed | ISI | ChemPort |
  12. Wüthrich, K. NMR of Proteins and Nucleic Acids. (John Wiley & Sons, New York; 1986).
  13. Roder, H. Meth. Enzymol. 176, 446−473 (1989). | Article | PubMed | ISI | ChemPort |
  14. Roder, H. & Wüthrich, K. Proteins 1, 34−42 (1986). | PubMed | ChemPort |
  15. Udgaonkar, J.B. & Baldwin, R.L. Nature 335, 694−699 (1988). | Article | PubMed | ISI | ChemPort |
  16. Roder, H., Elöve, G.A. & Englander, S.W. Nature 335, 700−704 (1988). | Article | PubMed | ISI | ChemPort |
  17. Udgaonkar, J.B. & Baldwin, R.L. Proc. natn. Acad. Sci. U.S.A. 87, 8197−8201 (1990). | ChemPort |
  18. Elöve, G.A. & Roder, H. ACS Symp. Ser. 470, 50−63 (1991). | ISI |
  19. Baldwin, R.L. & Roder, H. Curr. Biol. 1, 218−220 (1991). | ChemPort |
  20. Englander, S.W. & Mayne, L. A. Rev. Biophys. Biomol. Struct. 21, 243−265 (1992). | Article | ISI | ChemPort |
  21. Baldwin, R.L. Curr. Opin. Struct. Biol. 3, 84−91 (1993). | Article | ISI | ChemPort |
  22. Blum, A.D., Smallcombe, S.H. & Baldwin, R.L. J. molec. Biol. 118, 305−316 (1978). | PubMed | ISI | ChemPort |
  23. Adler, M. & Scheraga, H.A. Biochemistry 27, 2471−2480 (1988). | PubMed | ISI | ChemPort |
  24. Kautz, R.A. & Fox, R.O. Protein Sci. 2, 851−858 (1993). | PubMed | ISI | ChemPort |
  25. Frieden, C., Hoeltzli, S.D. & Ropson, I.J. Protein Sci. 2, 2007−2014 (1993). | PubMed | ISI | ChemPort |
  26. Hoeltzli, S.D., Ropson, I.J. & Frieden, C. In Techniques in Protein Chemistry V. 455−465 (Academic Press, San Diego; 1994). | ChemPort |
  27. Marion, D., Ikura, M., Tschudin, R. & Bax, A. J. Magn. Reson. 85, 393−399 (1989). | ISI | ChemPort |
  28. Ruiz-Cabello, J., Vuister, G.W., Moonen, C.T.W., van Gelderen, P., Cohen, J.S. & van Zijl, P.C.M. J. Magn. Reson. 100, 282−302 (1992). | ChemPort |
  29. Kuwajima, K., Mitani, M. & Sugai, S. J. molec. Biol. 206, 547−561 (1989). | PubMed | ISI | ChemPort |
  30. Ikeguchi, M., Kuwajima, K., Mitani, M. & Sugai, S. Biochemistry 25, 6965−6972 (1986). | PubMed | ISI | ChemPort |
  31. Jennings, P.A. & Wright, P.E. Science 262, 892−895 (1993). | PubMed | ISI | ChemPort |
  32. Hughson, F.M., Wright, P.E. & Baldwin, R.L. Science 249, 1544−1548 (1990). | PubMed | ISI | ChemPort |
  33. Hughson, F.M., Barrick, D. & Baldwin, R.L. Biochemistry 30, 4113−4118 (1991). | PubMed | ISI | ChemPort |
  34. Baum, J., Dobson, C.M., Evans, P.A. & Hanley, C. Biochemistry 28, 7 (1989). | PubMed | ISI | ChemPort |
  35. Chyan, C.L., Wormald, C., Dobson, C.M., Evans, P.A. & Baum, J. Biochemistry 32, 5681−5691 (1993). | PubMed | ISI | ChemPort |
  36. Schulman, B.A., Redfield, C., Peng, Z.Y., Dobson, C.M. & Kim, P.S. J. molec. Biol. in the press.
  37. Ban, N. & Dobson, C. Nature struct. Biol. 2, 871−875 (1995). | PubMed | ISI | ChemPort |
  38. Jeng, M.-F., Englander, S.W., Elöve, G.A., Wand, A.J. & Roder, H. Biochemistry 29, 10433−10437 (1990). | PubMed | ISI | ChemPort |
  39. Marmorino, J.L. & Pielak, G.J. Biochemistry 34, 3140−3143 (1995). | PubMed | ISI | ChemPort |
  40. Dobson, C.M. Current Biology 4, 636−640 (1994). | PubMed | ISI | ChemPort |
  41. Alexandrescu, A.T., Evans, P.A., Pitkeatly, M., Baum, J. & Dobson, C.M. Biochemistry 32, 1707−1718 (1993). | PubMed | ISI | ChemPort |
  42. Ewbank, J.J. & Creighton, T.E. Nature 350, 518−520 (1991). | Article | PubMed | ISI | ChemPort |
  43. Peng, Z.-y. & Kim, P.S. Biochemistry 33, 2136−2141 (1994). | PubMed | ISI | ChemPort |
  44. Ewbank, J.J. & Creighton, T.E. Biochemistry 32, 3677−3693 (1993). | PubMed | ISI | ChemPort |
  45. Wu, L.C., Peng, Z.-y. & Kim, P.S. Nature struct. Biology 2, 281−286 (1995). | ISI | ChemPort |
  46. Sali, A., Shaknovich, E. & Karplus, M. Nature 369, 248−251 (1994). | Article | PubMed | ISI | ChemPort |
  47. Gutin, A.M., Abkevich, V.I. & Shakhnovich, E.I. Biochemistry 34, 3066−3076 (1995). | PubMed | ISI | ChemPort |
  48. Acharya, K.R., Ren, J., Stuart, D.I. & Phillips, D.C. J. molec. Biol. 221, 571−581 (1991). | Article | PubMed | ISI | ChemPort |
  49. Wolynes, P.G., Onuchic, J.N. & Thirumalai, D. Science 267, 1619−1620 (1995). | PubMed | ISI | ChemPort |
  50. Sosnick, T.R., Mayne, L., Hiller, R. & Englander, S.W. Nature struct. Biology 1, 149−156 (1994). | ISI | ChemPort |
  51. Schmid, F.X. In Protein Folding. (Ed. Creighton, T.E.) 197−241 (W.H. Freeman & Co., New York; 1992). | ChemPort |
  52. Odefey, C., Mayr, L.M. & Schmid, F.X. J. molec. Biol. 245, 69−78 (1995). | Article | PubMed | ISI | ChemPort |
  53. Creighton, T.E. Biochem. J. 270, 1−16 (1990). | PubMed | ISI | ChemPort |
  54. Weissman, J.S. & Kim, P.S. Proc. natn. Acad. Sci. U.S.A. 89, 9900−9904 (1992). | ChemPort |
  55. Elöve, G.A., Bhuyan, A.K. & Roder, H. Biochemistry 33, 6925−6935 (1994). | PubMed | ISI | ChemPort |
  56. Wu, L., Laub, P.B., Elöve, G.A., Carey, J. & Roder, H. Biochemistry 32, 10271−10276 (1993). | PubMed | ISI | ChemPort |
  57. Dobson, C.M. Nature struct. Biology 2, 513−517 (1995). | ISI | ChemPort |
  58. Jackson, S.E. & Fersht, A.R. Biochemistry 30, 10428−10435 (1991). | PubMed | ISI | ChemPort |
  59. Alexander, P., Orban, J. & Bryan, P. Biochemistry 31, 7243−7248 (1992). | PubMed | ISI | ChemPort |
  60. Viguera, A.R., Martúnez, J.C., Filimonov, V.V., Mateo, P.L. & Serrano, L. Biochemistry 33, 2142−2150 (1994). | PubMed | ISI | ChemPort |
  61. Kragelund, B.B., Robinson, C.V., Knudsen, J., Dobson, C.M. & Poulsen, F.M. Biochemistry 34, 7217−7224 (1995). | PubMed | ISI | ChemPort |
  62. Schindler, T., Herrler, M., Marahiel, M.A. & Schmid, F.X. Nature atruct. Biology 2, 663−673 (1995). | ChemPort |
  63. Khorasanizadeh, S., Peters, I.D., Butt, T.R. & Roder, H. Biochemistry 32, 7054−7063 (1993). | PubMed | ISI | ChemPort |
  64. Houry, W.A., Rothwarf, D.M. & Scheraga, H.A. Biochemistry 33, 2516−2530 (1994). | PubMed | ISI | ChemPort |
  65. Jones, C.M. et al. Proc. natn. Acad. Sci. U.S.A. 90, 11860−11864 (1993). | ChemPort |
  66. Regenfuss, P., Clegg, R.M., Fulwyler, M.J., Barrantes, F.J. & Jovin, T.M. Rev. Sci. Instrum. 56, 283−290 (1985). | Article | ISI | ChemPort |
  67. Kraulis, P.J. J. Appl. Cryst. 24, 946−950 (1991). | Article | ISI |
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