Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Pinpointing a puzzling polymerase

One of the surprising discoveries in the genomic age was the presence in plant genomes of two noncanonical DNA-dependent RNA polymerases involved in small RNA–mediated gene silencing. Two recent studies map the binding sites of RNA polymerase V, uncovering new mysteries concerning the targeting and function of this enigmatic enzyme.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Pol V binding sites.

References

  1. Haag, J.R. & Pikaard, C.S. Nat. Rev. Mol. Cell Biol. 12, 483–492 (2011).

    Article  CAS  Google Scholar 

  2. Law, J.A. & Jacobsen, S.E. Nat. Rev. Genet. 11, 204–220 (2010).

    Article  CAS  Google Scholar 

  3. Zhong, X. et al. Nat. Struct. Mol. Biol. 19, 870–875 (2012).

    Article  CAS  Google Scholar 

  4. Wierzbicki, A.T. et al. Genes Dev. doi:10.1101/gad.197772.112, published online 1 August 2012.

    Article  CAS  Google Scholar 

  5. Douet, J., Tutois, S. & Tourmente, S. PLoS Genet. 5, e1000690 (2009).

    Article  Google Scholar 

  6. López, A., Ramirez, V., Garcia-Andrade, J., Flors, V. & Vera, P. PLoS Genet. 7, e1002434 (2011).

    Article  Google Scholar 

  7. Pontes, O., Costa-Nunes, P., Vithayathil, P. & Pikaard, C.S. Mol. Plant 2, 700–710 (2009).

    Article  CAS  Google Scholar 

  8. Mosher, R.A. et al. Nature 460, 283–286 (2009).

    Article  CAS  Google Scholar 

  9. Wierzbicki, A.T., Haag, J.R. & Pikaard, C.S. Cell 135, 635–648 (2008).

    Article  CAS  Google Scholar 

  10. Law, J.A. et al. Curr. Biol. 20, 951–956 (2010).

    Article  CAS  Google Scholar 

  11. Huettel, B. et al. EMBO J. 25, 2828–2836 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Rebecca A Mosher.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mosher, R. Pinpointing a puzzling polymerase. Nat Struct Mol Biol 19, 865–866 (2012). https://doi.org/10.1038/nsmb.2374

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsmb.2374

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing