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July 2012 Volume 19 No 7

Mammalian dioxygenase ALKBH2 searches the genome for alkylation lesions and mediates their direct repair. He and colleagues now show that ALKBH2 probes the stability of base pairs to find DNA damage, and its oxidative demethylation mechanism ensures that only cognate lesions are processed, similar to the mechanism of gear wheels for a safe lock. Image by John A. Shaw from Shutterstock. pp 671–676

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