Abstract
Dyneins are the largest of the cytoskeletal motor proteins, and their mechanochemical behavior is complex. Recent high-resolution crystallographic structures have revealed new surprises regarding motor domain organization and new insights into how force and movement are achieved.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Vallee, R.B. et al. Nat. Cell Biol. 14, 224–230 (2012).
Carter, A.P. et al. Science 331, 1159–1165 (2011).
Kon, T. et al. Nat. Struct. Mol. Biol. 18, 638–642 (2011).
Kon, T. et al. Nature advance online publication, doi:10.1038/nature10955 (6 February 2012).
Schmidt, H. et al. Nat. Struct. Mol. Biol. 5, 492–497 (2012).
Burgess, S.A. et al. Nature 421, 715–718 (2003).
Kon, T. et al. Nat. Struct. Mol. Biol. 12, 513–519 (2005).
Roberts, A.J. et al. Cell 136, 485–495 (2009).
Gibbons, I.R. et al. J. Biol. Chem. 280, 23960–23965 (2005).
Kon, T. et al. Nat. Struct. Mol. Biol. 16, 325–333 (2009).
Carter, A.P. et al. Science 322, 1691–1695 (2008).
Höök, P. et al. Biochemistry 48, 2710–2713 (2009).
Hendricks, A.G. et al. Curr. Biol. 20, 697–702 (2010).
McKenney, R.J. et al. Cell 141, 304–314 (2010).
Reck-Peterson, S.L. et al. Cell 126, 335–348 (2006).
Gennerich, A. et al. Cell 131, 952–965 (2007).
Höök, P. et al. J. Biol. Chem. 280, 33045–33054 (2005).
Hafezparast, M. et al. Science 300, 808–812 (2003).
Ori-McKenney, K.M. et al. Nat. Cell Biol. 12, 1228–1234 (2010).
Acknowledgements
The authors are supported by US National Institutes of Health grant GM47434 (to R.B.V.). We thank S. Weil for critical reading of this manuscript.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Höök, P., Vallee, R. Dynein dynamics. Nat Struct Mol Biol 19, 467–469 (2012). https://doi.org/10.1038/nsmb.2290
Published:
Issue Date:
DOI: https://doi.org/10.1038/nsmb.2290
This article is cited by
-
Cytoplasmic dynein and early endosome transport
Cellular and Molecular Life Sciences (2015)