The Cbl family of RING finger ubiquitin ligases regulates signaling in many systems. Two new studies provide a structural basis for how phosphorylation of a specific tyrosine in the Cbl proteins enhances their ubiquitin ligase activity, giving insight into how ubiquitination by Cbl proteins is restricted to specific substrates.
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Kales, S., Ryan, P. & Lipkowitz, S. Cbl exposes its RING finger. Nat Struct Mol Biol 19, 131–133 (2012). https://doi.org/10.1038/nsmb.2241
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DOI: https://doi.org/10.1038/nsmb.2241
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