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Modeling the endoplasmic reticulum unfolded protein response

Nature Structural & Molecular Biology volume 17, pages 924–925 (2010)Cite this article

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A detailed quantitative model of signaling by IRE1 sheds light on the mechanism of its activation by endoplasmic reticulum stress and addresses a long-standing controversy in the field.

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Figure 1: Model for IRE1 activity.
Figure 2: Models and measurements of key events in the UPR (from ref. 9).

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Acknowledgements

We are indebted to D. Pincus and M. Chevalier for sharing their model computer code and for access to primary data and to H. El-Samad for fruitful discussions. D.R. is a Wellcome Trust Principal Research Fellow.

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Authors and Affiliations

  1. Amos Onn is at the Open University of Israel, Tel Aviv, Israel.,

    Amos Onn

  2. David Ron is at the Institute of Metabolic Sciences, University of Cambridge, Cambridge, United Kingdom.,

    David Ron

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  1. Amos Onn
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  2. David Ron
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Correspondence to David Ron.

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Onn, A., Ron, D. Modeling the endoplasmic reticulum unfolded protein response. Nat Struct Mol Biol 17, 924–925 (2010). https://doi.org/10.1038/nsmb0810-924

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