Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Coil-in-to snRNP assembly and Cajal bodies

Eukaryotic cells have numerous non–membrane bound bodies whose functions are often unclear. On page 403 of this issue, Strzelecka and colleagues provide evidence that the ability to form Cajal bodies increases the rate of small nuclear ribonucleoprotein (snRNP) biogenesis and/or function. This supports the hypothesis that some cellular bodies form to increase the rates of assembly of multicomponent cellular machines.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Interpretation of coilin effects on snRNP biogenesis and function.

References

  1. Anderson, P. & Kedersha, N. Nat. Rev. Mol. Cell Biol. 10, 430–436 (2009).

    Article  CAS  Google Scholar 

  2. Matera, A.G., Izaguire-Sierra, M., Praveen, K. & Rajendra, T.K. Dev. Cell 17, 639–647 (2009).

    Article  CAS  Google Scholar 

  3. Collier, S. et al. Mol. Biol. Cell 17, 2942–2951 (2006).

    Article  CAS  Google Scholar 

  4. Liu, J.L. et al. Mol. Biol. Cell 20, 1661–1670 (2009).

    Article  CAS  Google Scholar 

  5. Tucker, K.E. et al. J. Cell Biol. 154, 293–307 (2001).

    Article  CAS  Google Scholar 

  6. Walker, M.P., Tian, L. & Matera, A.G. PLoS One 4, e6171 (2009).

    Article  Google Scholar 

  7. Gall, J.G. Annu. Rev. Cell Dev. Biol. 16, 273–300 (2000).

    Article  CAS  Google Scholar 

  8. Cioce, M. & Lamond, A.I. Annu. Rev. Cell Dev. Biol. 21, 105–131 (2005).

    Article  CAS  Google Scholar 

  9. Strzeleck, M. et al. Nat. Struct. Mol. Biol. 17, 403–409 (2010).

    Article  Google Scholar 

  10. Whittom, A.A., Xu, H. & Hebert, M.D. Cell. Mol. Life Sci. 65, 1256–1271 (2008).

    Article  CAS  Google Scholar 

  11. Klingauf, M., Stanek, D. & Neugebauer, K.M. Mol. Biol. Cell 17, 4974–4981 (2006).

    Article  Google Scholar 

  12. Brangwynne, C.P. et al. Science 324, 1729–1732 (2009).

    Article  CAS  Google Scholar 

  13. Pellizzoni, L., Yong, J. & Dreyfuss, G. Science 298, 1775–1779 (2002).

    Article  CAS  Google Scholar 

  14. Buchan, J.R., Muhlrad, D. & Parker, R. J. Cell Biol. 183, 441–455 (2008).

    Article  CAS  Google Scholar 

  15. Narayanaswamy, R. et al. Proc. Natl. Acad. Sci. USA 106, 10147–10152 (2009).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Roy Parker.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yoon, JH., Parker, R. Coil-in-to snRNP assembly and Cajal bodies. Nat Struct Mol Biol 17, 391–393 (2010). https://doi.org/10.1038/nsmb0410-391

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsmb0410-391

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing