Myotonic dystrophy is caused by expanded CTG repeats, and the expression of these repeats as RNA leads to the sequestration of the splicing factor muscleblind-like (MBNL1) to the CUG RNA. Two mouse models for myotonic dystrophy—mice expressing expanded CUG repeats and mice lacking functional MBNL1—now reveal ∼100 new mis-splicing events and a new class of aberrantly regulated mRNAs.
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Voelker, R., Berglund, J. Two ways to misregulate mRNAs in myotonic dystrophy. Nat Struct Mol Biol 17, 141–142 (2010). https://doi.org/10.1038/nsmb0210-141
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DOI: https://doi.org/10.1038/nsmb0210-141
