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Nature Structural & Molecular Biology 16, 902 - 903 (2009)
doi:10.1038/nsmb0909-902
When chromatin meets splicing
Alberto R Kornblihtt1, Ignacio E Schor1, Mariano Allo1 & Benjamin J Blencowe2
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Alberto R. Kornblihtt, Ignacio E. Schor and Mariano Allo are at the Departamento de Fisiología
Biología Molecular, LFBM and IFIBNE-CONICET, Facultad de Ciencias Exactas Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina. - Benjamin J. Blencowe is at the Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada.
Correspondence to: Alberto R Kornblihtt1 e-mail: ark@fbmc.fcen.uba.ar
Correspondence to: Benjamin J Blencowe2 e-mail: b.blencowe@utoronto.ca
Abstract
Using bioinformatics analysis of previously published global genome deep-sequencing data, two papers now show that DNA sequences associated with nucleosomes are preferentially located in exons. The correlation between nucleosome distribution and the exon-intron organization of genes may have a key role in exon recognition at the pre-mRNA level during co-transcriptional splicing, consistent with previous findings indicating chromatin-mediated regulation of alternative splicing.
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