1. Shan Zha, Cristian Boboila, Frederick W. Alt are at the Howard Hughes Medical Institute, The Children's Hospital, The CBR institute of Biomedical Research, Harvard Medical School, Boston, Massachusetts, USA.

Correspondence to: Frederick W Alt¹ e-mail: alt@enders.tch.harvard.edu

Abstract

The Mre11 protein has well-documented functions in the repair of DNA double-strand breaks via homologous recombination. Now, several new studies reveal that Mre11 also has a role in mammalian DNA double-strand break repair by nonhomologous end joining.

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