Review abstract
Focus on Protein Folding
- Focus issue:
- June 2009 Volume 16, No 6
Nature Structural & Molecular Biology 16, 574 - 581 (2009)
Published online: 3 June 2009 | doi:10.1038/nsmb.1591
Converging concepts of protein folding in vitro and in vivo
F Ulrich Hartl1 & Manajit Hayer-Hartl1
Abstract
Most proteins must fold into precise three-dimensional conformations to fulfill their biological functions. Here we review recent concepts emerging from studies of protein folding in vitro and in vivo, with a focus on how proteins navigate the complex folding energy landscape inside cells with the aid of molecular chaperones. Understanding these reactions is also of considerable medical relevance, as the aggregation of misfolding proteins that escape the cellular quality-control machinery underlies a range of debilitating diseases, including many age-onset neurodegenerative disorders.
- Max Planck Institute of Biochemistry, Department of Cellular Biochemistry, Martinsried, Germany.
Correspondence to: F Ulrich Hartl1 e-mail: uhartl@biochem.mpg.de
Correspondence to: Manajit Hayer-Hartl1 e-mail: mhartl@biochem.mpg.de
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