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Nature Structural & Molecular Biology 16, 457–459 (1 May 2009) | doi:10.1038/nsmb0509-457

Nuclear transport comes full circle

Erik W Debler , G|[uuml]|nter Blobel & Andr|[eacute]| Hoelz

One hallmark in evolution was the formation of the cell nucleus, which sequesters the genetic information encoded by DNA. This compartmentalization resulted in the segregation of key steps in the pathways from DNA to protein.