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Metabolism control by the circadian clock and vice versa

Nature Structural & Molecular Biology volume 16, pages 462–467 (2009)Cite this article

Abstract

Circadian rhythms govern a wide variety of physiological and metabolic functions in most organisms. At the heart of these regulatory pathways in mammals is the clock machinery, a remarkably coordinated transcription-translation system that relies on dynamic changes in chromatin states. Recent findings indicate that regulation also goes the other way, as specific elements of the clock can sense changes in cellular metabolism. Understanding in full detail the intimate links between cellular metabolism and the circadian clock machinery will provide not only crucial insights into system physiology but also new avenues toward pharmacological intervention of metabolic disorders.

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Figure 1: The interplay between the circadian clock and cellular metabolism occurs at various levels.
Figure 2: By activating Sirt1, NAD+ conjoins two feedback loops necessary for cross-talk between the circadian clock and metabolite production.

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Acknowledgements

We thank D. Wallace and all the members of our laboratory for stimulating discussions and reading of the manuscript. Work in our laboratory is supported by the US National Institutes of Health, the Cancer Research Coordinating Committee of the University of California and the Institut National de la Santé et la Recherche Médicale (INSERM U904, France).

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  1. Kristin Eckel-Mahan and Paolo Sassone-Corsi are in the Department of Pharmacology, University of California, Irvine, California, USA.,

    Kristin Eckel-Mahan & Paolo Sassone-Corsi

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Correspondence to Paolo Sassone-Corsi.

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Eckel-Mahan, K., Sassone-Corsi, P. Metabolism control by the circadian clock and vice versa. Nat Struct Mol Biol 16, 462–467 (2009). https://doi.org/10.1038/nsmb.1595

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