News and Views
Nature Structural & Molecular Biology 16, 457 - 459 (2009)
doi:10.1038/nsmb0509-457
Nuclear transport comes full circle
Erik W Debler1, Günter Blobel1 & André Hoelz1
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Erik W. Debler, Günter Blobel & André Hoelz are at Rockefeller University, Howard Hughes Medical Institute, New York, New York, USA.
e-mail: edebler@rockefeller.edu
e-mail: blobel@rockefeller.edu
e-mail: hoelza@rockefeller.edu
Abstract
Previous structural snapshots of snurportin have provided insights into its cargo recognition and nuclear import. The structure of snurportin bound to its export factor CRM1 now reveals the molecular basis of its recycling back into the cytoplasm, illuminating general principles of nuclear export sequence recognition.
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