News and Views
Nature Structural & Molecular Biology 16, 346 - 347 (2009)
doi:10.1038/nsmb0409-346
miR-9 and TLX: chasing tails in neural stem cells
Ahmet M Denli1, Xinwei Cao1 & Fred H Gage1
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Ahmet M. Denli, Xinwei Cao and Fred H. Gage are at the Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.
e-mail: gage@salk.edu
Abstract
Development and maintenance of an organism require the precise spatiotemporal orchestration of stem cell proliferation and differentiation. In neurogenesis, a microRNA and an orphan nuclear receptor comprise a negative feedback loop that regulates neural stem cell fate.
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